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KMID : 0361120080220020274
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Korean Journal of Transplantation
2008 Volume.22 No. 2 p.274 ~ p.277
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Acute Tubular Necrosis in a Kidney Transplant Patient Using Benzbromarone: A Case Report
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Han Seung-Seok
Ha Jong-Won
Kim Sun-Moon
Yoo Seol-Bong
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Abstract
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Benzbromarone is a uricosuric agent for hyperuricemia and gout. Some of its well-known side effects include hypersensitivity, renal calculi, and gastrointestinal problems. Although the drug was withdrawn from U.S. market due to severe hepatotoxicity, it is still available in some countries including Korea. We describe a 19-year-old male who was admitted with general weakness and azotemia after use of benzbromarone. A kidney biopsy revealed acute tubular necrosis without an evidence of urate nephropathy. After discontinuation of benzbromarone, the renal function returned to baseline. This is the first case of acute tubular necrosis associated with benzbromarone use.
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KEYWORD
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Benzbromarone, Kidney recipient, Acute tubular necrosis
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